If oligohydramnios is observed, MICARDIS HCT tablets should be discontinued unless they are considered life-saving for the mother. The highest doses administered to mice 1000 mg kg day ostaa micardis ups toimitettu and rats 100 mg kg day are, on mg m2 basis, about 59 and 13 times, respectively, the maximum recommended human dose MRHD of telmisartan. Patients with depletion of intravascular volume should have the condition corrected or telmisartan tablets should be initiated under close medical supervision see WARNINGS, Hypotension in Volume Depleted Patients. The antihypertensive effect of telmisartan is not influenced by patient age, gender, weight or body mass index. It is, therefore, recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing telmisartan to avoid possible over- or under-digitalization. The antihypertensive effect was independent of age or gender.